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List of side effects of estradiol which may occur as a result of its use or have been associated with estrogen and/or progestogen therapy includes: [1] [2]. Gynecological: changes in vaginal bleeding, dysmenorrhea, increase in size of uterine leiomyomata, vaginitis including vaginal candidiasis, changes in cervical secretion and cervical ectropion, ovarian cancer, endometrial hyperplasia ...
[84] [85] [86] The preceding side effects of synthetic estrogens do not appear to occur in pregnant women, who already have very high estrogen levels. [84] This suggests that these effects are due to estrogenic activity. [84] Synthetic estrogens have markedly stronger effects on the liver and hepatic protein synthesis than natural estrogens.
The general side effects of EE include breast tenderness and enlargement, headache, fluid retention, and nausea among others. [7] In men, EE can additionally cause breast development, feminization in general, hypogonadism, and sexual dysfunction. Rare but serious side effects include blood clots, liver damage, and cancer of the uterus. [7]
Pregnancy Symptoms Week 1. It's a bit of a mind-bender, but you aren't actually pregnant during what doctors call "week one" of pregnancy. Instead, week one starts on the first day of your last ...
Average number of moderate-to-severe hot flashes per week with placebo and different doses of oral estradiol in menopausal women [40] [41]. Estradiol is used in menopausal hormone therapy to prevent and treat moderate to severe menopausal symptoms such as hot flashes, vaginal dryness and atrophy, and osteoporosis (bone loss). [11]
Side effects of estrogens like estrone include breast tenderness, breast enlargement, headache, nausea, fluid retention, and edema, among others. [5] Estrone is a naturally occurring and bioidentical estrogen, or an agonist of the estrogen receptor , the biological target of estrogens like endogenous estradiol . [ 5 ]
Estradiol levels are minimal and according to most laboratories range from 20 to 80 pg/mL during the early to mid follicular phase (or the first week of the menstrual cycle, also known as menses). [ 63 ] [ 64 ] Levels of estradiol gradually increase during this time and through the mid to late follicular phase (or the second week of the ...
As such, pregnancy is a markedly hyperestrogenic and hyperprogestogenic state. [42] [43] Levels of estradiol and progesterone are both up to 100-fold higher during pregnancy than during normal menstrual cycling. [44] Pseudopregnancy simulates the hormonal profile of the first trimester of pregnancy. [45]