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Tizanidine, sold under the brand name Zanaflex among others, is an alpha-2 (α 2) adrenergic receptor agonist, [2] similar to clonidine, that is used to treat muscle spasticity due to spinal cord injury, multiple sclerosis, and spastic cerebral palsy. [3] Effectiveness appears similar to baclofen or diazepam. [4] It is taken by mouth. [5]
Cyclobenzaprine, sold under several brand names including, historically, Flexeril, is a muscle relaxer used for muscle spasms from musculoskeletal conditions of sudden onset. [5] It is not useful in cerebral palsy. [5] It is taken by mouth. [5] Common side effects include headache, feeling tired, dizziness, and dry mouth. [5]
Tizanidine was found to decrease the average frequency of headaches per week, the headache intensity, and the mean headache duration. [15] Through studies, Fluoxetine resulted in better mood ratings and "significant increases in headache-free days". [16]
GLP-1 drugs do a lot more than just help you lose weight. They can help your heart, brain, and more, but beware what they might do to muscle and skin. The Terrible—and Amazing—Side Effects of ...
Tizanidine is perhaps the most thoroughly studied clonidine analog, and is an agonist at α 2-adrenergic receptors, but reduces spasticity at doses that result in significantly less hypotension than clonidine. [26]
More than 40 percent of American adults struggle with obesity, and many are turning to weight loss pills. Obesity is associated with an increased risk of chronic health conditions like type 2 ...
Mounjaro vs. Ozempic: Which Is Better for Weight Loss? This article was reviewed by Craig Primack, MD, FACP, FAAP, FOMA. They’re both once-a-week injectable drugs designed to help patients with ...
Specific locations and functions of the α receptors. Image from Basic and Clinical Pharmacology by Bertram Katzung, et al. [1] Alpha blockers, also known as α-blockers or α-adrenoreceptor antagonists, are a class of pharmacological agents that act as antagonists on α-adrenergic receptors (α-adrenoceptors).
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