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Chorionic hematoma is the pooling of blood between the chorion, a membrane surrounding the embryo, and the uterine wall. [2] It occurs in about 3.1% of all pregnancies, [2] it is the most common sonographic abnormality and the most common cause of first trimester bleeding. [3]
Recurrent miscarriage or recurrent pregnancy loss (RPL) is the spontaneous loss of 2-3 pregnancies that is estimated to affect up to 5% of women. The exact number of pregnancy losses and gestational weeks used to define RPL differs among medical societies. [ 1 ]
The risk of miscarriage is not likely decreased by discontinuing SSRIs before pregnancy. [75] Some available data suggest that there is a small increased risk of miscarriage for women taking any antidepressant, [76] [77] though this risk becomes less statistically significant when excluding studies of poor quality. [74] [78]
Approximately 80% of pregnancy loss occurs in the first trimester, with a decrease in risk after 12 weeks gestation. Some variables, such as the mother's being older or chromosomal abnormalities, possess a higher likelihood of causing multiple miscarriages. [46]
Different chromosomes are observed at different frequencies depending on the type of CPM observed. [2] The pregnancy outcome is strongly chromosome specific. The most frequently seen trisomic cells in confined placental mosaicism involve chromosomes 2, 3, 7, 8 and 16. The next frequently involved are 9, 13, 15, 18, 20 and 22. [8]
Cervical weakness may cause miscarriage or preterm birth during the second and third trimesters. It has been estimated that cervical insufficiency complicates about 1% of pregnancies, and that it is a cause in about 8% of women with second trimester recurrent miscarriages. [2]
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