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As of 2016 the evidence on the efficacy of radiation therapy was considered inadequate in quantity and quality, and difficult to interpret because of uncertainty about the natural history of Dupuytren's disease. [33] Needle aponeurotomy is most effective for Stages I and II, covering 6–90 degrees of deformation of the finger.
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Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum that dismantles collagen.It is used as a powder-and-solvent injection kit for the treatment of Dupuytren's contracture, a condition where the fingers bend towards the palm and cannot be fully straightened, and Peyronie's disease, a connective tissue disorder involving the growth of fibrous ...
The causes of some deformities, such as Dupuytren's contracture, are difficult to determine exactly, however chances of developing the deformity may be increased by certain chronic behaviours or disease. [3] Consequences can be similar to trauma related ones, in that joint use may be disrupted. [20]
Knuckle pads are benign subcutaneous fibrotic nodules that are seen in the finger joints and/or the extensor area of the foot. [6] [7] [8] From a clinical perspective, these are well-defined, non-compressible, freely moveable lesions that resemble warts and primarily affect the dorsal portion of the proximal interphalangeal (PIP) and, less frequently, the metacarpophalangeal (MCP) joints.
Garrod's pads are named after Archibald Garrod who first documented them in 1904 in association with Dupuytren's contracture. [3] H.A. Bird described them as an incidental finding in a professional violinist and proposed that they arise in such cases due to repeated extreme tension of the extensor tendons over the interphalangeal joints. [4]
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