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A shortage in tetrahydrofolic acid (FH4) can cause megaloblastic anemia. [2] [3] [4] Methotrexate acts on dihydrofolate reductase, like pyrimethamine or trimethoprim, as an inhibitor and thus reduces the amount of tetrahydrofolate made. This may result in megaloblastic anemia.
Macrocytic anemias have several causes but with the implementation of folic acid fortification in North America, folate deficiency has become a rare cause of megaloblastic macrocytic anemia in that part of the world. [1] In this region, Vitamin B 12 deficiency is a far more common cause of megaloblastic macrocytic anemia. [1]
Megaloblastic anemia is a type of macrocytic anemia. An anemia is a red blood cell defect that can lead to an undersupply of oxygen. [1] Megaloblastic anemia results from inhibition of DNA synthesis during red blood cell production. [2] When DNA synthesis is impaired, the cell cycle cannot progress from the G2 growth stage to the mitosis (M ...
Symptoms of anemia may include tiredness/weakness (especially with exertion where increased energy is needed), shortness of breath (anemia triggers your body to look for more oxygen), other non ...
Methotrexate, formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. [4] It is used to treat cancer , autoimmune diseases , and ectopic pregnancies . [ 4 ] Types of cancers it is used for include breast cancer , leukemia , lung cancer , lymphoma , gestational trophoblastic disease , and osteosarcoma . [ 4 ]
Main symptoms that may appear in anemia [20] The hand of a person with severe anemia (on the left, with ring) compared to one without (on the right). A person with anemia may not have any symptoms, depending on the underlying cause, and no symptoms may be noticed, as the anemia is initially mild, and then the symptoms become worse as the anemia worsens.
Signs of folate deficiency anemia most of the time are subtle. [4] Anemia (macrocytic, megaloblastic anemia) can be a sign of advanced folate deficiency in adults. [1] Folate deficiency anemia may result in feeling tired, weakness, changes to the color of the skin or hair, open sores on the mouth, shortness of breath, palpitations, lightheadedness, cold hands and feet, headaches, easy bleeding ...
Methotrexate can cause termination or deformity in fetuses and is a common abortifacient, ... anemia, or chlorisis which often caused death. [160] ...
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