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Trials in emergency department settings support the use of ondansetron to abort vomiting episodes associated with gastroenteritis and dehydration. [20] A randomized controlled trial using a single dose of oral ondansetron in children with presumably viral gastroenteritis found it to be highly effective in stopping vomiting and increasing the effectiveness of oral rehydration therapy, thereby ...
There are few side effects related to the use of 5-HT 3 antagonists; the most common are constipation or diarrhea, headache, and dizziness. [28] Unlike antihistamines with antiemetic properties such as cyclizine, 5-HT 3 antagonists do not produce sedation, nor do they cause extrapyramidal effects, as phenothiazines (such as prochlorperazine ...
Midazolam (Versed) is given at the onset of anesthesia and has been shown in recent trials to be as effective as ondansetron, but most effective when used in combination with ondansetron. [15] Lorazepam (Ativan) is said to be very good as an adjunct treatment for nausea along with first line medications such as Compazine. [citation needed]
Common side effects include tiredness, loss of appetite, diarrhea, abdominal pain, hiccups, itchiness, pneumonia, and blood pressure changes. [5] Other severe side effects may include anaphylaxis. [5] While use in pregnancy does not appear to be harmful, such use has not been well studied. [7]
Common side effects include nausea, pain at the site of injection, and headache. [2] It may also cause a temporary increase in blood pressure and decrease in heart rate after each dose, and darkening of the gums, face, and breasts. [4] The medication is a peptide and acts by activating the melanocortin receptors. [1] [5]
Horton argued that the treatment of a non-fatal condition did not justify the use of a drug with potentially lethal side effects, and that the FDA should have revoked the approval for alosetron sooner when postmarketing surveillance revealed that many patients had suffered constipation necessitating surgical intervention and ischaemic colitis.
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Dolasetron is a well-tolerated drug with few side effects. Headache, dizziness, and constipation are the most commonly reported side effects associated with its use. There is a potential for prolonging of the QT interval to occur as well. There have been no significant drug interactions reported with this drug's use.
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