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Bebtelovimab is a neutralizing human immunoglobulin G1 (IgG1) monoclonal antibody, isolated from a patient who has recovered from the Coronavirus disease 2019 (COVID-19), directed against the spike (S) protein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that can potentially be used for immunization against COVID-19. [6]
This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.
A study of samples collected in Manaus between November 2020 and January 2021, indicated that the Gamma variant is 1.4–2.2 times more transmissible and was shown to be capable of evading 25–61% of inherited immunity from previous coronavirus diseases, leading to the possibility of reinfection after recovery from an earlier COVID-19 ...
More specifically, IgG antibodies were detected in recovered patients’ samples for at least 115 days post-symptom onset. Notably, this is also the first study to successfully detect coronavirus ...
Studies show that some recovered patients who tested negative for coronavirus antibodies did develop T cells in response to their COVID-19 infection Scientists focus on how immune system T cells ...
The potential emergence of a SARS-CoV-2 variant that is moderately or fully resistant to the antibody response elicited by the COVID-19 vaccines may necessitate modification of the vaccines. [451] The emergence of vaccine-resistant variants is more likely in a highly vaccinated population with uncontrolled transmission. [ 452 ]
The reason COVID-19 cases increased this summer is likely because people who hadn’t been recently vaccinated or infected had fewer antibodies at the ready to fight off the first sign of the ...
Over 2021–22, two Cochrane reviews found insufficient evidence for using neutralizing monoclonal antibodies to treat COVID-19 infections. [53] [54] The reviews applied only to people who were unvaccinated against COVID‐19, and only to the COVID-19 variants existing during the studies, not to newer variants, such as Omicron. [54]
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