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In large studies, women taking bisphosphonates for osteoporosis have had unusual fractures ("bisphosphonate fractures") in the femur (thigh bone) in the shaft (diaphysis or sub-trochanteric region) of the bone, rather than at the femoral neck, which is the most common site of fracture. However, these fractures are rare (12 in 14,195 women ...
Nitrogen containing bisphosphonates are the current most used drugs in the class because of their potency. [15] Studies have showed that nitrogen on bisphosphonates forms hydrogen bond with threonine (Thr201) and the carbonyl part of Lysine (Lys200) on target enzyme, therefore enhancing the binding of the complex. Altering the position of ...
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Bisphosphonates are popular drugs for treatment of osteoporosis. [1] Clodronic acid is a bisphosphonate used as a drug to treat osteoporosis. In biochemistry and medicinal chemistry, phosphonate groups are used as stable bioisosteres for phosphate, such as in the antiviral nucleotide analog, Tenofovir, one of the cornerstones of anti-HIV therapy.
Chữ Nôm (𡨸喃, IPA: [t͡ɕɨ˦ˀ˥ nom˧˧]) [5] is a logographic writing system formerly used to write the Vietnamese language.It uses Chinese characters to represent Sino-Vietnamese vocabulary and some native Vietnamese words, with other words represented by new characters created using a variety of methods, including phono-semantic compounds. [6]
Modrac Lake (Bosnian: Jezero Modrac) is an artificial lake in Bosnia and Herzegovina.Located in the municipality of Lukavac, it is home to many species of fish and is popular with fishermen.
Yuri Yulianovich Shevchuk (Russian: Юрий Юлианович Шевчук; born 16 May 1957) is a Soviet and Russian rock musician and singer/songwriter who leads the rock band DDT, which he founded with Vladimir Sigachyov in 1980.
The Ministry of Industry and Trade (MOIT, Vietnamese: Bộ Công thương) is the government ministry in Vietnam responsible for the advancement, promotion, governance, regulation, management and growth of industry and trade.