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While researching lysergic acid derivatives, Hofmann first synthesized LSD on November 16, 1938. [1] The main intention of the synthesis was to obtain a respiratory and circulatory stimulant (an analeptic). It was set aside for five years, until April 16, 1943, when Hofmann decided to take a second look at it.
Albert Hofmann (11 January 1906 – 29 April 2008) was a Swiss chemist known for being the first to synthesize, ingest, and learn of the psychedelic effects of lysergic acid diethylamide (LSD). Hofmann's team also isolated, named and synthesized the principal psychedelic mushroom compounds psilocybin and psilocin. [1]
Swiss chemist Albert Hofmann first synthesized LSD in 1938 from lysergic acid, a chemical derived from the hydrolysis of ergotamine, an alkaloid found in ergot, a fungus that infects grain. [19] [17] LSD was the 25th of various lysergamides Hofmann synthesized from lysergic acid while trying to develop a new analeptic, hence the alternate name ...
In 1907 Alfred Bertheim synthesized Arsphenamine, the first man-made antibiotic. In 1927 Erik Rotheim patented the first aerosol spray can. ... (LSD) Albert Hofmann ...
After the first draft, by his own account, he “just wasn’t happy with it,” he says. Some parts were “way too detailed,” others weren’t “detailed enough” and, overall, he didn't ...
Lysergic acid is generally produced by hydrolysis [5] of natural lysergamides, but can also be synthesized in the laboratory by a complex total synthesis, for example by Robert Burns Woodward's team in 1956. [6] An enantioselective total synthesis based on a palladium-catalyzed domino cyclization reaction has been described in 2011 by Fujii and ...
A letter from Sidney Gottlieb regarding the use of LSD in 1953. Swiss chemist Albert Hofmann first synthesized LSD at Sandoz Laboratories in 1938, while searching for medicinal ergot alkaloid derivatives, but its potential use as a psychedelic was not discovered until 1943. Sandoz made LSD available as a psychiatric drug in 1947.
In his debut memoir Source Code — which will be published on Tuesday, Feb. 4 — Bill Gates shared candid stories about his first experiences with alcohol and drugs, including LSD