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CD68 immunostaining demonstrating macrophages and giant cells in a case of xanthogranulomatous pyelonephritis. CD68 (Cluster of Differentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages (e.g., Kupffer cells, microglia). [5]
a membrane protein present on many hemopoietic cells and fibroblasts that acts as a ligand for CD2 and may be involved in T-cell function. CD59: Membrane attack complex inhibition factor (MACIF); MAC-inhibitory protein (MAC-IP); Antigen MEM43; Protectin: Immune system complement cascade regulatory factor; Homologous restriction factor(HRF ...
The CD nomenclature was proposed and established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), held in Paris in 1982. [4] [5] This system was intended for the classification of the many monoclonal antibodies (mAbs) generated by different laboratories around the world against epitopes on the surface molecules of leukocytes (white blood cells).
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VCP performs diverse functions through modulating the stability and thus the activity of its substrates. The general function of VCP is to segregate proteins from large protein assembly or immobile cellular structures such as membranes or chromatin, allowing the released protein molecules to be degraded by the proteasome.
3161 15366 Ensembl ENSG00000072571 ENSMUSG00000020330 UniProt O75330 Q00547 RefSeq (mRNA) NM_012485 NM_001142556 NM_001142557 NM_012484 NM_013552 RefSeq (protein) NP_001136028 NP_001136029 NP_036616 NP_036617 NP_038580 Location (UCSC) Chr 5: 163.46 – 163.49 Mb Chr 11: 40.59 – 40.62 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Hyaluronan-mediated motility receptor (HMMR), also ...
An organelle within the nucleus of eukaryotic cells which is composed of proteins, DNA, and RNA and serves as the site of ribosome synthesis. nucleoplasm. Also karyoplasm. All of the material enclosed within the nucleus of a cell by the nuclear envelope, analogous to the cytoplasm enclosed by the main cell membrane.
Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS.