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Giant-cell tumor of the bone (GCTOB), is a relatively uncommon bone tumor. It is characterized by the presence of multinucleated giant cells ( osteoclast -like cells). Malignancy in giant-cell tumor is uncommon and occurs in about 2% of all cases.
X-ray of a giant cell bone tumor in the head of the 4th metacarpal of the left hand. An arm bone tumor. Bone tumors are traditionally classified as noncancerous (benign) or cancerous (malignant). [1] Several features of bone tumors and soft tissue tumors overlap. [7] Their classification was revised by the World Health Organization (WHO) in ...
Tenosynovial giant cell tumor (TGCT) is a non-malignant tumor defined histologically as inclusions of “osteoclast-like” multinucleated giant cells, hemosiderin, and macrophages. [1] This histology can present one of 2 clinically distinct ways. TGCT tumors often develop from the lining of joints (also known as synovial tissue).
A giant cell (also known as a multinucleated giant cell, or multinucleate giant cell) is a mass formed by the union of several distinct cells (usually histiocytes), often forming a granuloma. [ 1 ] Although there is typically a focus on the pathological aspects of multinucleate giant cells (MGCs), they also play many important physiological roles.
Histologically, it is impossible to distinguish a Brown tumor of hyperparathyroidism from other giant cell lesions of bone. Rarely a focal collection of osteoclasts (brown tumor) may occur in relation to periosteum and be indistinguishable from a peripheral giant cell granuloma (giant cell epulis).
Osteosarcoma is the most common bone tumor in dogs and typically affects middle-aged large and giant breed dogs such as Irish Wolfhounds, Greyhounds, German Shepherds, Rottweilers, mountain breeds (Great Pyrenees, St. Bernard, Leonberger, Newfoundland), Doberman Pinschers and Great Danes. It has a 10-fold greater incidence in dogs than humans. [33]
Chondroblastoma is a rare, benign, locally aggressive bone tumor that typically affects the epiphyses or apophyses of long bones. [1] [2] It is thought to arise from an outgrowth of immature cartilage cells (chondroblasts) from secondary ossification centers, originating from the epiphyseal plate or some remnant of it.
Central giant-cell granuloma (CGCG) is a localised benign condition of the jaws. It is twice as common in females and is more likely to occur before age 30. Central giant-cell granulomas are more common in the anterior mandible, often crossing the midline and causing painless swellings. [1]
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