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The organic compound citrulline is an α-amino acid. [2] Its name is derived from citrullus, the Latin word for watermelon.Although named and described by gastroenterologists since the late 19th century, it was first isolated from watermelon in 1914 by Japanese researchers Yatarō Koga (古賀彌太郎) and Ryō Ōtake (大嶽了) [3] [4] and further codified by Mitsunori Wada of Tokyo ...
Citrulline is not one of the 20 standard amino acids encoded by DNA in the genetic code. Instead, it is the result of a post-translational modification. Citrullination is distinct from the formation of the free amino acid citrulline as part of the urea cycle or as a byproduct of enzymes of the nitric oxide synthase family.
Citrulline Arginine. Anti-citrullinated protein antibodies (ACPAs) are autoantibodies (antibodies to an individual's own proteins) that are directed against peptides and proteins that are citrullinated. They are present in the majority of patients with rheumatoid arthritis. Clinically, cyclic citrullinated peptides (CCP) are frequently used to ...
Bahasa Indonesia; Ирон; Italiano ... Protein. 0.61 g. Vitamins and minerals. Vitamins: ... The amino acid citrulline is produced in watermelon rind. [31] [32 ...
In enzymology, a citrullinase (EC 3.5.1.20) is an enzyme that catalyzes the chemical reaction. L-citrulline + H 2 O L-ornithine + CO 2 + NH 3. Thus, the two substrates of this enzyme are L-citrulline and H 2 O, whereas its 3 products are L-ornithine, CO 2, and NH 3.
18416 Ensembl ENSG00000036473 ENSMUSG00000031173 UniProt P00480 P11725 RefSeq (mRNA) NM_000531 NM_008769 RefSeq (protein) NP_000522 NP_032795 Location (UCSC) Chr X: 38.35 – 38.42 Mb Chr X: 10.12 – 10.19 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Ornithine transcarbamylase (OTC) (also called ornithine carbamoyltransferase) is an enzyme (EC 2.1.3.3) that catalyzes the reaction ...
Citrullination is a modification of proteins where a nitrogen in the amino acid arginine is replaced with an oxygen, converting it into citrulline. The modified (citrullinated) protein may be identified by as foreign, provoking an autoimmune inflammation response. [1] Various kinds of citrullinated proteins have been detected in the joints of ...
Homocitrulline has been suggested as a confounding antigen for rheumatoid arthritis antibodies targeting citrullinated proteins/peptides. [1] Antibodies binding to homocitrulline-containing sequences have been found in rheumatoid arthritis patients' sera [2] [3] More recently, it has been shown that homocitrulline-containing proteins are present in rheumatoid arthritis (RA) joints. [4]