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high molecular weight iron dextran 165 000 low molecular weight iron dextran 289 000 - 444 000 34 000 - 60 000 750 000 150 000 150 000 Maximum approved dosage (mg) 100 100 125 200 510 20 mg per kg 1000 mg if patient weight is > 66 kg Test dose required Yes Yes No No No No No Iron concentration (mg/mL) 50 50 12.5 20 30 100 50
Iron dextran preparation [31] Routes Dosage forms Strengths Brand names Manufacturer Parenteral: Injection, for IV use: equivalent to 50 mg of elemental iron per mL: Dexferrum® American Regent Injection, for IV or IM use: equivalent to 50 mg of elemental iron per mL: INFeD® Watson
Iron isomaltoside 1000 (brand name Monofer) is a formulation of parenteral iron that has a matrix structure that results in very low levels of free iron and labile iron. It can be given at high doses – 20 mg/kg in a single visit – no upper dose limit.
ATC code B03 Antianemic preparations is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Iron sucrose is a dark brown liquid solution. It is administered intravenously and is only used when a patient with iron deficiency cannot be treated using oral iron options. [5] It is a generally effective drug, with more than 80% of patients responding to treatment. Iron sucrose has ~20 mg of iron per mL of solution.
Cosmofer is a treatment for iron deficiency anemia. The generic name of Cosmofer is low molecular weight iron dextran. Cosmofer was approved in 2001, and is available in more than 45 countries worldwide. It has a lower incidence of dextran-induced analphylaxis than older dextran-based products, although still requires a test dose. [12]
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Dextran is used to make microcarriers for industrial cell culture; Orally-administered dextran sodium sulphate is used to induce colitis in animal models of inflammatory bowel disease. [12] Dextran is a common model compound to test the potential of drug formulations to facilitate intestinal absorption via the paracellular route. [13]