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The formulations may differ in terms of pharmacokinetic properties, particularly bioavailability; some must be taken with meals, whereas others may be taken without regard to food. [30] The choline salt of fenofibrate is available in the United States, sold as Trilipix, and may be taken without regard to meals. [24] [31]
In combination with statin drugs, fibrates cause an increased risk of rhabdomyolysis, idiosyncratic destruction of muscle tissue, leading to kidney failure. The less lipophilic statins are less prone to cause this reaction, and are probably safer to be combined with fibrates than the more lipophilic statins are. Drug toxicity includes acute ...
The most common side effects are abdominal distension (bloating), abdominal pain (stomach ache), constipation, diarrhea, dry mouth, dyspepsia (heartburn), eructation (belching), flatulence (gas), nausea (feeling sick), abdominal discomfort, vomiting and raised blood levels of liver enzymes.
Fenofibrate/simvastatin, sold under the brand name Cholib, is a fixed-dose combination medication used to treat abnormal blood lipid levels when used in combination ...
The U.S. Food and Drug Administration (FDA) notified healthcare professionals of updates to the prescribing information concerning interactions between protease inhibitors and certain statin drugs. Protease inhibitors and statins taken together may increase the blood levels of statins and increase the risk for muscle injury (myopathy).
Common side effects include headache, dizziness, feeling tired, and intestinal upset. [3] Serious side effects may include angioedema, gallstones, liver problems, and muscle breakdown. [3] Use in pregnancy and breastfeeding is of unclear safety. [5] It belongs to the fibrates group of medications and works by decreasing the breakdown of lipids ...
WebMD is an American corporation which publishes online news and information about human health and well-being. [4] The WebMD website also includes information about drugs and is an important healthcare information website and the most popular consumer-oriented health site. [5] WebMD was started in 1998 by internet entrepreneur Jeff Arnold. [6]
Being a dual PPAR agonist, saroglitazar helps in controlling blood glucose and lipid parameters, especially high triglycerides and high non-HDL cholesterol. [3] [4] [5] A study done in rats concluded that saroglitazar has the potential to prevent the progression of retinopathy in diabetes patients. [6]