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Nicotinonitrile or 3-cyanopyridine is an organic compound with the formula NCC 5 H 4 N. The molecule consists of a pyridine ring with a nitrile group attached to the 3-position. A colorless solid, it is produced by ammoxidation of 3-methylpyridine: [2] H 3 CC 5 H 4 N + NH 3 + 1.5 O 2 → NCC 5 H 4 N + 3 H 2 O. Nicotinonitrile is a precursor to ...
In these conversions, chloride is displaced. [2] Pyrithione, the conjugate base of 2-mercaptopyridine-N-oxide, is a fungicide found in some shampoos. Oxidation 2-chloropyridine gives 2-chloropyridine-N-oxide. [5] The antihistamine pheniramine may be generated via the reaction of phenylacetonitrile with 2-chloropyridine in the presence of a base ...
The oxidation of pyridine can be achieved with a number of peracids including peracetic acid and perbenzoic acid. [3] Oxidation can also be effected by a modified Dakin reaction using a urea-hydrogen peroxide complex, [4] and sodium perborate [5] or, using methylrhenium trioxide (CH 3 ReO 3) as catalyst, with sodium percarbonate. [6]
3-Picoline is a useful precursor to agrochemicals, such as chlorpyrifos. [1] Chlorpyrifos is produced from 3,5,6-trichloro-2-pyridinol, which is generated from 3-picoline by way of cyanopyridine. This conversion involves the ammoxidation of 3-methylpyridine: CH 3 C 5 H 4 N + 1.5 O 2 + NH 3 → NCC 5 H 4 N + 3 H 2 O
2,6-Dichloropyridine is a chloropyridine with the formula C 5 H 3 Cl 2 N. A white solid, it is one of six isomers of dichloropyridine . It serves as a precursor to the antibiotic enoxacin , [ 2 ] as well as the drug and anpirtoline and the antifungal liranaftate .
A simple representative is N-methylpyridinium ([C 5 H 5 NCH 3] +). These pyridinium intermediates have been used as electrophiles in synthetic organic chemistry to build dearomatized congeners called dihydropyridines, as demonstrated in one example from Smith in 2021. [5]
3-Chloropyridine is an aryl chloride and isomer of chloropyridine with the formula C 5 H 4 ClN. It is a colorless liquid that is mainly used as a building block in organic synthesis. [1] The compound is a substrate for many coupling processes including the Heck reaction, [2] Suzuki reaction, [3] and Ullmann reaction. [4]
Picolinic acid is an organic compound with the formula NC 5 H 4 CO 2 H.It is a derivative of pyridine with a carboxylic acid (COOH) substituent at the 2-position. It is an isomer of nicotinic acid and isonicotinic acid, which have the carboxyl side chain at the 3- and 4-positions, respectively.