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[1] [3] [5] Originally thought to selectively act on serotonin , PBMA was subsequently found to act not only on serotonin but also on norepinephrine and dopamine similarly to PCA. [ 4 ] [ 6 ] [ 7 ] It has been reported to produce pharmacological effects that have been said to be "somewhat similar" or "indistinguishable" to those of lysergic ...
para-Bromoamphetamine (PBA), also known as 4-bromoamphetamine (4-BA), is an amphetamine derivative which acts as a serotonin-norepinephrine-dopamine releasing agent (SNDRA) and produces stimulant effects. Another related compound is para-bromomethamphetamine (PBMA) known by the codename V-111. [1]
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Studies in the 1970s found that a single dose of 10 mg/1 kg 4-CMA resulted in a decreased level of 5-hydroxytryptamine in the brain for several weeks. [ 12 ] 4-Chloromethamphetamine was identified outside of the laboratory for the first time at the Tomorrowland festival edition 2015, where a tablet was found in possession of a drug dealer (see ...
The full name of the chemical is 2,5-dimethoxy-4-bromoamphetamine. DOB has a stereocenter and R -(−)-DOB is the eutomer . This is an important finding as it is suggestive that it is targeting different receptors relative to most other phenethylamines (e.g. MDMA ) where the R -isomer serves as the distomer .
[3] [5] However, this was found to be due to rapid metabolism in the case of MCA, and inhibiting its metabolism resulted in potent neurotoxicity as with PCA. [5] Conversely, OCA still does not produce apparent neurotoxicity. [5] para-Bromoamphetamine (PBA) and para-bromomethamphetamine (PBMA) show similar serotonergic neurotoxicity to PCA and ...
A normal average dose of DOC ranges from 0.2–7.0 mg [19] the former producing threshold effects, and the latter producing extremely strong effects. Onset of the drug is 1–3 hours, peak and plateau at 4–8 hours, and a gradual come down with residual stimulation at 9-20h. After effects can last well into the next day. [19] [20]