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Clomifene is a nonsteroidal triphenylethylene derivative that acts as a selective estrogen receptor modulator (SERM). [14] It consists of a non-racemic mixture of zuclomifene (~38%) and enclomifene (~62%), each of which has unique pharmacologic properties. [31] It is a mixed agonist and antagonist of the estrogen receptor (ER).
Enclomifene (INN Tooltip International Nonproprietary Name), or enclomiphene (USAN Tooltip United States Adopted Name), a nonsteroidal selective estrogen receptor modulator of the triphenylethylene group, acts by antagonizing the estrogen receptor (ER) in the pituitary gland, which reduces negative feedback by estrogen on the hypothalamic-pituitary-gonadal axis, thereby increasing gonadotropin ...
Subsequently, clomiphene citrate was discovered in 1951, which was then approved by the Food and Drug Administration (FDA) in 1967. [3] In 1978, bromocriptine gained FDA approval for hyperprolactinemia and later proved effective in treating prolactinemia-related infertility. [4] As a breakthrough, hMG/hCG protocols for pre-IVF treatment were ...
Clomiphene is a selective estrogen receptor modulator (SERM). [5] It is the most widely used fertility drug. [6] Other medications in this class include tamoxifen and raloxifene, although both are not as effective as clomiphene and are thus less widely used for fertility purposes. [7]
Mesterolone, sold under the brand name Proviron among others, is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of low testosterone levels. [2][3] It has also been used to treat male infertility, although this use is controversial. [2][4][5] It is taken by mouth. [2]
Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA). [5] It is used in the treatment of various conditions, most notably obsessive–compulsive disorder but also many other disorders, including hyperacusis, panic disorder, major depressive disorder, trichotillomania, [6] body dysmorphic disorder [7] [8] [9] and chronic pain. [5]