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By reducing LDL cholesterol, statins can also help lower a person’s risk for cardiovascular diseases such as heart failure, coronary heart disease, heart attack, and stroke.
“Risk models don’t determine who is recommended to take statins, guidelines do,” Khan said. “I think the most important thing is the determination of when it will be recommended to ...
Persons taking gemfibrozil, a non-statin lipid-lowering drug Atorvastatin Combining gemfibrozil and a statin increases risk of rhabdomyolysis and subsequently kidney failure [62] [63] Persons taking the anticoagulant warfarin: Any statin The statin use may require that the warfarin dose be changed, as some statins increase the effect of ...
[22] [23] Another consequence of taking statins is the risk of developing new-onset diabetes, which is more prominent in individuals with high TG levels and body mass index (BMI). [19] However, the risk is far outweighed by the benefits from statin therapy for the reduction in cardiovascular outcomes. [20]
A risk exists of muscle damage (myopathy and rhabdomyolysis) with statins. Hypercholesterolemia is not a risk factor for mortality in persons older than 70 years and risks from statin drugs are more increased after age 85. [2] Fibrates are indicated for hypertriglyceridemia. Fibrates typically lower triglycerides by 20% to 50%.
Many people don’t want to take cholesterol-lowering drugs, and some people can’t take them. Statins are effective and considered safe for most people, but they raise the risk of side effects ...
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