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For those with signs of hyperandrogenism (excessive androgen hormones) and other hormonal imbalances, spironolactone may be an effective treatment for female pattern hair loss. Spironolactone ...
Spironolactone is a once-a-day tablet that can stop hair loss from progressing and encourage new hair growth. It’s especially useful for women with hormonal issues like PCOS. It may take six to ...
Spironolactone can slow down this type of hair loss by reducing androgen production and blocking androgen receptors in the hair follicle. Minoxidil , an FDA-approved OTC topical medication option ...
Spironolactone can be used in the treatment of female-pattern hair loss (pattern scalp hair loss in women). [68] There is tentative low quality evidence supporting its use for this indication. [69] Although apparently effective, not all cases of female-pattern hair loss are dependent on androgens. [70]
Other options include topical or systemic spironolactone or flutamide, although they have a high incidence of feminising side effects and are better tolerated in female androgenic hair loss. More advanced cases may be resistant or unresponsive to medical therapy, however, and require hair transplantation .
The AR antagonism of spironolactone mostly underlies its antiandrogenic activity and is the major mechanism responsible for its therapeutic benefits in the treatment of androgen-dependent conditions like acne, hirsutism, and pattern hair loss and its usefulness in hormone therapy for transgender women.
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