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Copper deficiency, or hypocupremia, is defined as insufficient copper to meet the body's needs, or as a serum copper level below the normal range. [1] Symptoms may include fatigue, decreased red blood cells, early greying of the hair, and neurological problems presenting as numbness, tingling, muscle weakness, and ataxia. [2]
Copper deficiency is a major issue in global food production, resulting in losses in yield and reduced quality of output. Nitrogen fertilizers can worsen copper deficiency in agricultural soils. [citation needed] The world's two most important food crops, rice and wheat, are highly susceptible to copper deficiency.
Familial benign copper deficiency, also known as Familial benign hypocupremia is a rare genetic disorder which is characterized by hypocupremia that causes symptoms such as epilepsy, hypotonia, seborrheic skin, thriving failure and mild anemia. [2] Radiological findings include tibia and femur spurring. [3]
Copper deficiency-associated conditions (peripheral neuropathy, ... the patient can begin recovery as early as 2 to 12 weeks after the onset of the condition.
Copper deficiency can manifest in parallel with vitamin B12 and other nutritional deficiencies. [9] The most common cause of copper deficiency is a remote gastrointestinal surgery, such as gastric bypass surgery, due to malabsorption of copper, or zinc toxicity. Fluorine deficiency: Increased dental caries and possibly osteoporosis
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Both of these conditions, deficiency and excess, can lead to tissue injury and disease. However, due to homeostatic regulation, the human body is capable of balancing a wide range of copper intakes for the needs of healthy individuals. [45] Many aspects of copper homeostasis are known at the molecular level. [46]
11977 Ensembl ENSG00000165240 ENSMUSG00000033792 UniProt Q04656 Q64430 RefSeq (mRNA) NM_000052 NM_001282224 NM_001109757 NM_009726 RefSeq (protein) NP_000043 NP_001269153 NP_001103227 NP_033856 Location (UCSC) Chr X: 77.91 – 78.05 Mb Chr X: 105.07 – 105.17 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ATP7A, also known as Menkes' protein (MNK), is a copper-transporting P-type ...
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