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In coeliac disease, anti-actin antibody levels correlate with the level of intestinal damage. [2] [3] In autoimmune hepatitis, anti-actin antibody levels correlate with patterns of immune recognition, [4] the pattern of recognition was specific to a small percentage of autoimmune hepatitis type 1 or cryptogenic hepatitis patients. [5]
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Moreover, analysis of the correlation of anti-CCP antibody titre with RA disease activity yielded conflicting results. [13] [14] However, novel test systems utilizing ACPA have been developed. Citrullinated vimentin is a very promising autoantigen in RA, and a suitable tool for studying this systemic autoimmune disease. Vimentin is secreted and ...
It is imperative that the binding of the fluorophore to the antibody itself does not interfere with the immunological specificity of the antibody or the binding capacity of its antigen. [ 4 ] [ 5 ] Immunofluorescence is a widely used example of immunostaining (using antibodies to stain proteins) and is a specific example of immunohistochemistry ...
Actin, cytoplasmic 2, or gamma-actin is a protein that in humans is encoded by the ACTG1 gene. [5] Gamma-actin is widely expressed in cellular cytoskeletons of many tissues; in adult striated muscle cells, gamma-actin is localized to Z-discs and costamere structures, which are responsible for force transduction and transmission in muscle cells.
Profilin is an actin-binding protein involved in the dynamic turnover and reconstruction of the actin cytoskeleton. [1] It is found in most eukaryotic organisms. Profilin is important for spatially and temporally controlled growth of actin microfilaments, which is an essential process in cellular locomotion and cell shape changes.
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