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Ephedra is widely used by athletes as a performance-enhancing drug, [13] despite a lack of evidence that it improves athletic performance. [14] [15] Ephedra may also be used as a precursor in the illicit manufacture of methamphetamine. [16] Ephedra has been used as a weight-loss aid, sometimes in combination with aspirin and caffeine.
Dietary supplements based on or including elements of ECA were popular through the 1990s and early 2000s, but the marketing of ephedra- or ephedrine-containing stimulant combinations for weight loss and bodybuilding is now restricted or illegal in the United States and the Netherlands due to reports of heart attack, stroke, and death associated ...
Ephedrine promotes modest short-term weight loss, [24] specifically fat loss, but its long-term effects are unknown. [25] In mice, ephedrine is known to stimulate thermogenesis in the brown adipose tissue , but because adult humans have only small amounts of brown fat, thermogenesis is assumed to take place mostly in the skeletal muscle .
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