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The surface of the rough endoplasmic reticulum (often abbreviated RER or rough ER; also called granular endoplasmic reticulum) is studded with protein-manufacturing ribosomes giving it a "rough" appearance (hence its name). [7] The binding site of the ribosome on the rough endoplasmic reticulum is the translocon. [8]
Valosin-containing protein (VCP) or transitional endoplasmic reticulum ATPase (TER ATPase) also known as p97 in mammals and CDC48 in S. cerevisiae, is an enzyme that in humans is encoded by the VCP gene. [5] [6] [7] The TER ATPase is an ATPase enzyme present in all eukaryotes and archaebacteria.
In mammalian organisms, COPII vesicles that have budded from exit sites in the endoplasmic reticulum lose their coats and fuse to form the vesicular-tubular cluster (VTC). Retrieval (or retrograde) transport in COPI vesicles returns many of the lost ER resident proteins back to the endoplasmic reticulum. Forward (or anterograde) transport moves ...
The endoplasmic reticulum (ER) is a synthesis and transport organelle that branches into the cytoplasm in plant and animal cells. [3] The Golgi apparatus is a series of multiple compartments where molecules are packaged for delivery to other cell components or for secretion from the cell. [ 4 ]
The translocon (also known as a translocator or translocation channel) is a complex of proteins associated with the translocation of polypeptides across membranes. [1] In eukaryotes the term translocon most commonly refers to the complex that transports nascent polypeptides with a targeting signal sequence into the interior (cisternal or lumenal) space of the endoplasmic reticulum (ER) from ...
ER retention refers to proteins that are retained in the endoplasmic reticulum, or ER, after folding; these are known as ER resident proteins. Protein localization to the ER often depends on certain sequences of amino acids located at the N terminus or C terminus. These sequences are known as signal peptides, molecular signatures, or sorting ...
Endoplasmic reticulum resident proteins (23 P) Pages in category "Endoplasmic reticulum" The following 5 pages are in this category, out of 5 total.
This important enzyme complex is located within the membrane of the endoplasmic reticulum, and catalyzes the terminal reactions in both glycogenolysis and gluconeogenesis. [8] The G6Pase complex is most abundant in liver tissue, but also present in kidney cells, small intestine, pancreatic islets and at a lower concentration in the gallbladder.