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The tunnels were a vibrant part of the OKC landscape, including several shops and restaurants, but lost much of their popularity with the end of the last oil boom. [1] Originally named the Conncourse, in honor of Oklahoma City banker Jack Conn, [2] it was renamed the Underground after an extensive facelift conducted by architect Rand Elliott. [3]
Legends Tower is planned to be a mixed-use building with hotel, residential, and retail functions, including a 350-key Hyatt hotel, 1,776 apartments, and 110,000 square feet (10,000 m 2) of retail stores and restaurants. [5] [6] [13] The top floors of the building would feature a restaurant and observation deck with views of the city. [1]
In physiology, aldosterone escape is a term that has been used to refer to two distinct phenomena involving aldosterone that are exactly opposite each other: Escape from the sodium -retaining effects of excess aldosterone (or other mineralocorticoids ) in primary hyperaldosteronism , manifested by volume and/or pressure natriuresis .
Aldosterone stimulates Na + and water reabsorption from the gut, salivary and sweat glands in exchange for K +. Aldosterone stimulates secretion of H + via the H+/ATPase in the intercalated cells of the cortical collecting tubules; Aldosterone upregulates expression of NCC in the distal convoluted tubule chronically and its activity acutely. [18]
The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2. [5] MR is a receptor with equal affinity for mineralocorticoids and glucocorticoids.
A mineralocorticoid receptor antagonist (MRA or MCRA) [1] or aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid receptors. This group of drugs is often used as adjunctive therapy, in combination with other drugs, for the management of chronic heart failure .
Aldosterone has effects on most or all cells of the body but, clinically, the most important actions are in the kidney, on cells of the late distal convoluted tubule and medullary collecting duct. In the principal cells aldosterone increases activity of basolateral membrane sodium-potassium ATPase and apical epithelial sodium channels, ENaC ...
The first Toby Keith's I Love This Bar & Grill restaurants opened in 2005 in Oklahoma, [3] Keith's native state, in Oklahoma City and at the Hard Rock Hotel and Casino in Tulsa. Restaurants at the Chickasaw Nation's WinStar World Casino in Thackerville, [4] Oklahoma and in Las Vegas, Nevada, soon followed. The Oklahoma locations are operated by ...