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Cortisone is a naturally-occurring corticosteroid metabolite that is also used as a pharmaceutical prodrug. It is converted by the body into cortisol, which has anti-inflammatory and immunosuppressive effects. Learn about its properties, uses, risks and misconceptions.
Deflazacort is a corticosteroid used to treat various inflammatory and autoimmune conditions, including Duchenne muscular dystrophy (DMD). It is a prodrug that is metabolized to the active 21-desacetyldeflazacort, and has a lower impact on bone density and carbohydrate metabolism than other corticosteroids.
Medroxyprogesterone acetate (MPA) is a progestin hormone used for birth control, menopause, and other conditions. It is sold under the brand name Depo-Provera and other names, and can be taken by mouth, sublingual, or injection.
A prodrug is a medication or compound that is metabolized into an active drug after intake. Learn about the history, classification and examples of prodrugs, and how they improve bioavailability, selectivity and safety of drugs.
Progesterone is a progestogen and a neurosteroid with various medical uses. Its ATC code is G03DA04, according to the World Health Organization classification system. Oral progesterone may increase breast cancer risk, while vaginal progesterone may have unclear effects.
Corticosteroids are steroid hormones produced in the adrenal cortex or synthesized as drugs. They have various physiological and medical functions, such as regulating inflammation, metabolism, and immune response, but also have side effects and contraindications.
Allopregnanolone is a natural hormone derived from progesterone that acts on GABA receptors in the brain. It is approved as a medication for moderate to severe postpartum depression, but has side effects such as sedation and euphoria.
Many women stop taking combined hormonal contraceptives because they are concerned about weight gain; however, the link remains uncertain. [40] The effect of combined hormonal contraceptives on mood is unclear at this point. There have been some large cohort studies suggesting there may be an association with mood-related side-effects.