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Ibuprofen was derived from propionic acid by the research arm of Boots Group during the 1960s. [81] The name is derived from the 3 functional groups: isobutyl (ibu) propionic acid (pro) phenyl (fen). [82] Its discovery was the result of research during the 1950s and 1960s to find a safer alternative to aspirin.
The brand first entered the American market in 1984 through Whitehall [3] (itself a division of Wyeth, which was purchased by Pfizer in 2009), [4] the same year ibuprofen gained Food and Drug Administration (FDA) approval for over-the-counter (OTC) sales in the United States (being available via prescription since 1974). [5]
Ibuprofen, an analgesic and non-steroidal anti-inflammatory drug (NSAID), [1] is sold under many brand-names around the world. The most common are Brufen (its earliest registered trademark), Advil, Motrin, and Nurofen .
An International Nonproprietary Name (INN) is an official generic and nonproprietary name given to a pharmaceutical substance or an active ingredient, [1] encompassing compounds, peptides and low-molecular-weight proteins (e.g., insulin, hormones, cytokines), as well as complex biological products, such as those used for gene therapy. [2]
NSAID identification on label of generic ibuprofen, an over-the-counter non-steroidal anti-inflammatory drug Non-steroidal anti-inflammatory drugs [ 1 ] [ 3 ] ( NSAID ) [ 1 ] are members of a therapeutic drug class which reduces pain , [ 4 ] decreases inflammation , decreases fever , [ 1 ] and prevents blood clots .
Opioids are among the world's oldest known drugs. [13] [14] Use of the opium poppy for medical, recreational, and religious purposes can be traced to the 4th century BCE, when Hippocrates wrote about it for its analgesic properties, stating, "Divinum opus est sedare dolores." ("Divine work is the easing of pain") [15]
Stewart Sanders Adams OBE (16 April 1923 – 30 January 2019) was an English pharmacist, and bioengineer who was part of a team from Boots which developed the painkiller ibuprofen in 1961. Ibuprofen is now on the World Health Organization's Model List of Essential Medicines and is one of the world's best-selling drugs. [1]
Haleon plc is a British multinational consumer healthcare company with headquarters in Weybridge, England. [3] It is one of the largest consumer healthcare businesses in the world, with brands including Sensodyne toothpaste, Panadol and Advil painkillers, and Centrum vitamins. [4]
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