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  2. Sickle cell disease - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_disease

    Base-pair substitution that causes sickle cell anemia. The gene defect is a single nucleotide mutation of the β-globin gene, which results in glutamate being substituted by valine at position 6 of the β-globin chain. [62] Hemoglobin S with this mutation is referred to as HbS, as opposed to the normal adult HbA.

  3. Beta thalassemia - Wikipedia

    en.wikipedia.org/wiki/Beta_thalassemia

    Hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for both alpha and beta thalassemia. It involves replacing the dysfunctional stem cells in the bone marrow with healthy cells from a well-matched donor.

  4. Betibeglogene autotemcel - Wikipedia

    en.wikipedia.org/wiki/Betibeglogene_autotemcel

    Effectiveness was established based on achievement of transfusion independence, which is attained when the participant maintains a predetermined level of hemoglobin without needing any red blood cell transfusions for at least 12 months. Of 41 participants receiving betibeglogene autotemcel, 89% achieved transfusion independence. [5]

  5. Hemoglobin C - Wikipedia

    en.wikipedia.org/wiki/Hemoglobin_C

    HbC can combine with other abnormal hemoglobins and cause serious hemoglobinopathies. Individuals with sickle cell–hemoglobin C (HbSC), have inherited the gene for sickle cell disease (HbS) from one parent and the gene for hemoglobin C disease (HbC) from the other parent. Since HbC does not polymerize as readily as HbS, there is less sickling ...

  6. New sickle cell treatment sparks feelings of hope and some ...

    www.aol.com/sickle-cell-treatment-sparks...

    The FDA is reviewing a new drug for sickle cell disease that uses CRISPR to edit DNA. Black patients with the disease are excited and hopeful about the treatment.

  7. Sickle cell-beta thalassemia - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell-beta_thalassemia

    Treatment is the same as for patients with sickle cell disease. Patients may receive hydroxyurea to induce the protective effects of increased fetal hemoglobin production. They may also benefit from blood transfusions especially during vaso-occlusive crises.

  8. Sickle cell trait - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_trait

    Sickle cell disease is a blood disorder wherein there is a single amino acid substitution in the hemoglobin protein of the red blood cells, which causes these cells to assume a sickle shape, especially when under low oxygen tension.

  9. Hemoglobin O-Arab - Wikipedia

    en.wikipedia.org/wiki/Hemoglobin_O-Arab

    When combined with Hemoglobin S (β^6Glu → Val) it causes a severe form of Sickle cell disease known as Hemoglobin S/O-Arab. Detection of Hb O-Arab can be carried out with a blood test, identifying the carries of hemoglobinopathies, so as to inform patients their chances of producing an affected child and ensure appropriate guidance is given.