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Noonan syndrome with multiple lentigines (NSML) which is part of a group called Ras/MAPK pathway syndromes, [2] is a rare autosomal dominant, [3] multisystem disease caused by a mutation in the protein tyrosine phosphatase, non-receptor type 11 gene . The disease is a complex of features, mostly involving the skin, skeletal and cardiovascular ...
Lentigo simplex is the most common form of lentigo. [ 2 ] : 29 A single lesion or multiple lesions (lentigines) may be present at birth or more commonly first develop in early childhood. Lentigo simplex is not induced by sun exposure, and it is not associated with any medical diseases or conditions.
A lentigo (/ l ɛ n ˈ t aɪ ɡ oʊ /) (plural lentigines, / l ɛ n ˈ t ɪ dʒ ɪ n iː z /) is a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin. It is a harmless (benign) hyperplasia of melanocytes which is linear in its spread.
Rosacea. What it looks like: Rosacea causes redness and thick skin on the face, usually clustered in the center.Easy flushing, a stinging sensation, and small, pus-filled pimples are other common ...
[3] [1] Noonan syndrome is a type of RASopathy, the underlying mechanism for which involves attenuation of the RAS/MAPK cell signaling pathway. [1] The diagnosis may be suspected based on symptoms, medical imaging, and blood tests. [2] [4] Confirmation may be achieved with genetic testing. [2] No cure for NS is known. [5]
Familial multiple lentigines syndrome without systemic involvement [1] Generalized lentiginosis is inherited in an autosomal dominant manner: Specialty:
Lentigo in cats is a common dermatological condition characterized by the presence of small, flat, brownish spots on the skin — particularly around the lips, nose, and eyelid margins. Unlike in ...
Mitochondrial myopathy–encephalopathy–lactic acidosis–stroke syndrome; Multiple lentigines syndrome (cardiocutaneous syndrome, Gorlin syndrome II, lentiginosis profusa syndrome, LEOPARD syndrome, progressive cardiomyopathic lentiginosis) Multiple pterygium syndrome; Multiple sulfatase deficiency (Austin disease, mucosulfatidosis)