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  2. Eurycomanone - Wikipedia

    en.wikipedia.org/wiki/Eurycomanone

    Eurycomanone is a chemical compound that has been isolated from Eurycoma longifolia, also known as the longjack plant or tongkat ali. [1] Eurycomanone is distributed throughout the plant, with the highest concentration in leaves. Researchers measured 6.0568 μg/mL in leaves, and only 0.3533 μg/mL in roots. [2]

  3. Eurycoma longifolia - Wikipedia

    en.wikipedia.org/wiki/Eurycoma_longifolia

    Eurycoma longifolia (commonly called tongkat ali, Malaysian ginseng or long jack) [3] is a flowering plant in the family Simaroubaceae. It is native to Indochina (Cambodia, Laos, Malaysia, Myanmar, Thailand and Vietnam) and Indonesia (the islands of Borneo and Sumatra ), [ 4 ] but has also been found in the Philippines. [ 5 ]

  4. DNA damage (naturally occurring) - Wikipedia

    en.wikipedia.org/wiki/DNA_damage_(naturally...

    DNA damage inhibits M-CDKs which are a key component of progression into mitosis. In all eukaryotic cells, ATR and ATM are protein kinases that detect DNA damage. They bind to DNA damaged sites and activate Chk1, Chk2, and, in animal cells, p53. Together, these proteins make up the DNA damage response system.

  5. What to Know About Taking Tongkat Ali to Boost Testosterone - AOL

    www.aol.com/lifestyle/know-taking-tongkat-ali...

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  6. Postreplication repair - Wikipedia

    en.wikipedia.org/wiki/Postreplication_repair

    An arsenal of DNA repair mechanisms exists to repair various forms of damaged DNA and minimize genomic instability. Most DNA repair mechanisms require an intact DNA strand as template to fix the damaged strand. DNA damage prevents the normal enzymatic synthesis of DNA by the replication fork.

  7. Nucleotide excision repair - Wikipedia

    en.wikipedia.org/wiki/Nucleotide_excision_repair

    Nucleotide excision repair (NER) is a particularly important excision mechanism that removes DNA damage induced by ultraviolet light (UV). UV DNA damage results in bulky DNA adducts — these adducts are mostly thymine dimers and 6,4-photoproducts. Recognition of the damage leads to removal of a short single-stranded DNA segment that contains ...

  8. Double-strand break repair model - Wikipedia

    en.wikipedia.org/wiki/Double-strand_break_repair...

    Following the recruitment of the aforementioned proteins to DNA damage sites, they will in turn trigger cellular responses and repair pathways to mitigate and repair the damage caused. [4] In short, these vital upstream proteins and downstream repair pathways altogether forms the DDR, which plays a vital role in DSB repair pathways regulation.

  9. Molecular lesion - Wikipedia

    en.wikipedia.org/wiki/Molecular_lesion

    Ball and Stick Model of Double Helical DNA. A molecular lesion or point lesion is damage to the structure of a biological molecule such as DNA, RNA, or protein.This damage may result in the reduction or absence of normal function, and in rare cases the gain of a new function.

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