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Lysophosphatidic acid receptor 1 also known as LPA 1 is a protein that in humans is encoded by the LPAR1 gene. [ 4 ] [ 5 ] [ 6 ] LPA 1 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).
LPA acts as a potent mitogen due to its activation of three high-affinity G-protein-coupled receptors called LPAR1, LPAR2, and LPAR3 (also known as EDG2, EDG4, and EDG7). ). Additional, newly identified LPA receptors include LPAR4 (P2RY9, GPR23), LPAR5 (GPR92) and LPAR6 (P2RY5, G
The lysophosphatidic acid receptors (LPARs) are a group of G protein-coupled receptors for lysophosphatidic acid (LPA) that include: Lysophosphatidic acid receptor 1 (LPAR1; formerly known as EDG2, GPR26) Lysophosphatidic acid receptor 2 (LPAR2; formerly known as EDG4) Lysophosphatidic acid receptor 3 (LPAR3; formerly known as EDG7)
LPAR1: lysophosphatidic acid receptor 1 LPA EDG2 LPAR2: lysophosphatidic acid receptor 2 " EDG4 LPAR3: lysophosphatidic acid receptor 3 " EDG7 LPAR4: LPA 4: lysophosphatidic acid receptor 4 " GPR23 LPAR5: LPA 5: lysophosphatidic acid receptor 5 " GPR92 LPAR6: LPA 6: lysophosphatidic acid receptor 6 " P2RY5 S1PR1: sphingosine-1-phosphate ...
LPAR1 Protein encoded by this gene is a LPA receptor. Mediate functions such as proliferation, platelet aggregation, smooth muscle contraction, tumor cell invasion. REEP5 May promote functional cell surface expression of olfactory receptors. RTN1 Reticulon encoding gene, associated with the ER and involved in neuroendocrine secretion. RTN4
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CD97 can heterodimerize with the LPAR1, a canonical GPCR that is implied in tumor progression, to modulate synergistic functions and LPA-mediated Rho signaling. [26] [25] It has been shown that CD97 regulates localization and degradation of β-catenin. [24]
The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone, neuropeptide, neurotransmitter, and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins.