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  2. Neurosteroid - Wikipedia

    en.wikipedia.org/wiki/Neurosteroid

    Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors.

  3. List of neurosteroids - Wikipedia

    en.wikipedia.org/wiki/List_of_neurosteroids

    This is a list of neurosteroids, or natural and synthetic steroids that are active on the mammalian nervous system through receptors other than steroid hormone receptors. It includes inhibitory , excitatory , and neurotrophic neurosteroids as well as pheromones and vomeropherines .

  4. Allopregnanolone - Wikipedia

    en.wikipedia.org/wiki/Allopregnanolone

    Allopregnanolone is a naturally occurring neurosteroid which is made in the body from the hormone progesterone. [10] [11] As a medication, allopregnanolone is referred to as brexanolone, sold under the brand name Zulresso, [6] [12] and used to treat postpartum depression.

  5. GABA receptor agonist - Wikipedia

    en.wikipedia.org/wiki/GABA_receptor_agonist

    Gamma-aminobutyric acid, a GABA-B receptor agonist. A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects. [1]

  6. Pherine - Wikipedia

    en.wikipedia.org/wiki/Pherine

    Fasedienol (PH94B; Aloradine; 4,16-androstadien-3β-ol) is an investigational new drug proposed for the acute treatment of social anxiety disorder. [9] [12]PH10 is being developed as an indication for the acute treatment of depression.

  7. Pregnenolone - Wikipedia

    en.wikipedia.org/wiki/Pregnenolone

    Pregnenolone and its 3β-sulfate, pregnenolone sulfate, like dehydroepiandrosterone (DHEA), DHEA sulfate, and progesterone, belong to the group of neurosteroids that are found in high concentrations in certain areas of the brain, and are synthesized there. Neurosteroids affect synaptic functioning, are neuroprotective, and enhance myelinization.

  8. Neurosteroidogenesis inhibitor - Wikipedia

    en.wikipedia.org/wiki/Neurosteroidogenesis_inhibitor

    A neurosteroidogenesis inhibitor is a drug that inhibits the production of endogenous neurosteroids.Neurosteroids include the excitatory neurosteroids pregnenolone sulfate, dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEA-S), and the inhibitory neurosteroids allopregnanolone, tetrahydrodeoxycorticosterone (THDOC), and 3α-androstanediol, among others. [1]

  9. Progesterone - Wikipedia

    en.wikipedia.org/wiki/Progesterone

    Progesterone, like pregnenolone and dehydroepiandrosterone (DHEA), belongs to an important group of endogenous steroids called neurosteroids. It can be metabolized within all parts of the central nervous system. [77] Neurosteroids are neuromodulators, and are neuroprotective, neurogenic, and regulate neurotransmission and myelination. [78]