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Postherpetic neuralgia (PHN) is neuropathic pain that occurs due to damage to a peripheral nerve caused by the reactivation of the varicella zoster virus (herpes zoster, also known as shingles). PHN is defined as pain in a dermatomal distribution that lasts for at least 90 days after an outbreak of herpes zoster. [ 1 ]
Mirogabalin, under the brand name Tarlige, was approved for the treatment of neuropathic pain and postherpetic neuralgia in Japan in January 2019. [ 56 ] A longitudinal trend study analyzed multinational sales data, revealing an overall increase in gabapentinoid consumption across 65 countries and regions from 2008 to 2018.
Gabapentin, sold under the brand name Neurontin among others, is an anticonvulsant medication primarily used to treat neuropathic pain and also for partial seizures [10] [7] of epilepsy. It is a commonly used medication for the treatment of neuropathic pain caused by diabetic neuropathy, postherpetic neuralgia, and central pain. [11]
It has been FDA-approved to help control and treat seizures and to diminish a specific type of nerve pain called post-herpetic neuralgia that often follows a shingles' diagnosis.
The European Federation of Neurological Societies recommends pregabalin as a first-line agent for the treatment of pain associated with diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain. [54] A minority obtain substantial benefit, and a larger number obtain moderate benefit. [55]
EMA401 is a drug under development for the treatment of peripheral neuropathic pain.Trials were discontinued in 2015, with new trials scheduled to begin March, 2018. [1] It was initially established as a potential drug option for patients suffering pain caused by postherpetic neuralgia. [2]
Symptomatic treatment is often needed for the complication of postherpetic neuralgia. [65] However, a study on untreated shingles shows that, once the rash has cleared, postherpetic neuralgia is very rare in people under 50 and wears off in time; in older people, the pain wore off more slowly, but even in people over 70, 85% were free from pain ...
In Japan, the company submitted a marketing application for treatment of peripheral neuropathic pain. [5] The medication was approved for neuropathic pain and postherpetic neuralgia in Japan in January 2019.
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