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MSI is a good marker for detecting Lynch syndrome and determining a prognosis for cancer treatments. In 1996, the National Cancer Institute (NCI) hosted an international workshop on Lynch Syndrome, which led to the development of the "Bethesda Guidelines" and loci for MSI testing.
DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage.
Under the name constitutional mismatch repair-deficiency (CMMR-D), it has been mapped to MLH1, MSH2, MSH6 or PMS2. [2] Monoallelic mutations of these genes are observed in the condition known as Lynch syndrome or hereditary nonpolyposis colorectal cancer, while biallelic mutations are observed in CMMR-D. [3] People expressing the HNPCC (which itself is considered autosomal dominant) trait are ...
MMR/MSI tumor status was assessed by local testing assays (IHC, PCR, or NGS), or central testing (IHC), using the Ventana MMR RxDx Panel, when local results were unavailable. [19] In August 2024, the Food and Drug Administration approved dostarlimab with carboplatin and paclitaxel, followed by single-agent dostarlimab, for adults with primary ...
Mass spectrometry imaging (MSI) is a technique used in mass spectrometry to visualize the spatial distribution of molecules, as biomarkers, metabolites, peptides or proteins by their molecular masses. After collecting a mass spectrum at one spot, the sample is moved to reach another region, and so on, until the entire sample is scanned.
DNA mismatch repair protein Msh2 also known as MutS homolog 2 or MSH2 is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2.MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2, which forms a heterodimer with MSH6 to make the human MutSα mismatch repair complex.
Name used in the default map caption; image = USA Texas location map.svg The default map image, without "Image:" or "File:" image1 = Relief map of Texas.png An alternative map image, usually a relief map, which can be displayed via the relief or AlternativeMap parameters; top = 36.8 Latitude at top edge of map, in decimal degrees; bottom = 25.5 ...
Mumbai Metropolitan Region (ISO: Muṁbaī Mahānagara Pradēśa; abbreviated to MMR and previously also known as Greater Bombay Metropolitan Area), [6] [7] is a metropolitan area consisting of Mumbai and its satellite towns in the northern Konkan division of Maharashtra in western India.