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The thiazolidinediones / θ aɪ. ə ˌ z oʊ l ɪ d iː n ˈ d aɪ. oʊ n /, abbreviated as TZD, also known as glitazones after the prototypical drug ciglitazone, [1] are a class of heterocyclic compounds consisting of a five-membered C 3 NS ring.
Useful thiazolidines include the drug pioglitazone, the antibiotic penicillin, and N-Methyl-2-thiazolidinethione, an accelerator for the vulcanization of chloroprene rubbers. [4] Thiazolidines functionalized with carbonyls at the 2 and 4 positions, the thiazolidinediones, are drugs used in the treatment of diabetes mellitus type 2.
Pages in category "Thiazolidinediones" The following 13 pages are in this category, out of 13 total. This list may not reflect recent changes. ...
Diabetes medications: Insulin and thiazolidinediones. Beta-blockers: Propranolol and metoprolol. ... Meaning: If you aren't weighing yourself at a consistent time each day, expect to see different ...
Thiazolidinediones (13 P) Pages in category "Thiazolidines" The following 25 pages are in this category, out of 25 total. This list may not reflect recent changes. ...
Pioglitazone is used to lower blood glucose levels in type 2 diabetes either alone or in combination with sulfonylurea, metformin, or insulin. [1] The effects of pioglitazone have been compared in a Cochrane systematic review to that of other blood sugar lowering-medicine, including metformin, acarbose, and repaglinide, as well as with appropriate diet and exercise, not showing any benefit in ...
PPARγ (gamma) is the main target of the drug class of thiazolidinediones (TZDs), used in diabetes mellitus and other diseases that feature insulin resistance. It is also mildly activated by certain NSAIDs (such as ibuprofen) and indoles, as well as from a number of natural compounds. Known inhibitors include the experimental agent GW-9662.
Troglitazone is an antidiabetic and anti-inflammatory drug, and a member of the drug class of the thiazolidinediones. It was prescribed for people with diabetes mellitus type 2. [1] It was patented in 1983 and approved for medical use in 1997. [2] It was subsequently withdrawn.