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People with thalassemia traits (thalassemia minor or non transfusion dependent thalassemia), may not require medical or follow-up care after the initial diagnosis is made. [72] Occasionally transfusions may be necessary particularly around childbirth, surgery, or if other conditions provoke anemia.
Beta-thalassemia; Other names: Microcytemia, beta type [1] Beta thalassemia genetics, the picture shows one example of how beta thalassemia is inherited. The beta globin gene is located on chromosome 11. A child inherits two beta globin genes (one from each parent). Specialty: Hematology: Types: Thalassemia minor, intermediate and major [2] Causes
The Mentzer index, described in 1973 by William C. Mentzer, [1] is the MCV divided by the RBC count. It is said to be helpful in differentiating iron deficiency anemia from beta thalassemia trait.
Alpha-thalassemia (α-thalassemia, α-thalassaemia) is an inherited blood disorder and a form of thalassemia. Thalassemias are a group of inherited blood conditions which result in the impaired production of hemoglobin , the molecule that carries oxygen in the blood. [ 4 ]
Mild thalassemia : patients with thalassemia traits do not require medical or follow-up care after the initial diagnosis is made. [2] Patients with β-thalassemia trait should be warned that their condition can be misdiagnosed for the common Iron deficiency anemia.
Therefore, most transfusion-dependent thalassemia patients can be diagnosed within the first few years of life, which severe anemia, differed growth, jaundice and hepatosplenomegaly can be observed. Parameters for confirmation includes baseline hemoglobin level <7g/dL, enlargement of liver and spleen (>5 cm) and height in the first 10th percentile.
Beta-thalassemia has beta globin chains that are reduced and alpha-thalassemia has alpha globin chains that are also reduced. [5] This disorder is the most common autosomal recessive disorder in some countries. [6] Hemoglobin A2 is employed to diagnose thalassemia disorders, encompassing both beta and alpha types.
Thalassemia [3] (β-thalassemia Minor (i.e. Trait) & Major, and α-thalassemia, only when 3 gene loci defective: (--/-α)) Severe megaloblastic anemia; Hemolytic anemia; Sickle-cell anemia; Pyrimidine 5' nucleotidase deficiency [4] Alcoholism [5] Myelodysplastic syndromes; Sideroblastic anemia [6] Congenital dyserythropoietic anemia [7] Primary ...
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