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The time for “onset of action” is how long it takes for you to feel the drug’s effects. “Half-life” is a measure of how long it takes until half of the drug becomes inactivated. Since several of the benzos are metabolized into other benzos, to understand the full impact of a benzo, you must include its active (benzo-like) metabolites ...
Because of its water-soluble nature, midazolam has a rapid onset of action and can be used to manage status epilepticus when intravenous administration of other medications is not feasible. Midazolam can be used for anxiolysis and hypnosis during the maintenance phase of general anesthesia.
Onset of Action. IM: Sedation: Children: Within 5 minutes; Adults: ~15 minutes; IV: 3 to 5 minutes; Oral: 10 to 20 minutes; Intranasal (nasal spray): Within 10 minutes; Intranasal (solution, injection): Children: 5.55 ± 2.22 minutes (Lee-Kim 2004); Adults: Within 5 minutes
Midazolam has a faster onset and shorter duration of action than other benzodiazepines such as diazepam and lorazepam lending itself to greater flexibility in dosing than other benzodiazepines. The kidneys excrete midazolam and its active metabolite.
Midazolam is a short-acting benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders.
Following IV administration, the onset of sedative, anxiolytic, and amnesic action usually occurs within 1–5 minutes. Induction of anesthesia usually occurs in about 1.5 minutes when midazolam is administered concurrently with opiate agonists and in 2–2.5 minutes when administered without an opiate agonist or other sedatives.
Midazolam: imidazobenzodiazepine; act via benodiazepine receptor in CNS; linked and facilitate action of the GABA receptor; chloride channel activation -> hyperpolarises membrane.
Midazolam has a rapid onset of action following intravenous, intramuscular, oral, nasal, and rectal administration. Only 50% of an orally administered dose reaches the systemic circulation due to extensive first-pass metabolism.
It has a rapid onset of action (5 to 6 min) because at physiologic pH it is lipophilic. It is about twice as potent as diazepam, and it has a more rapid onset and shorter duration of action.34 Because of this, midazolam has become a popular sedative, especially as a continuous infusion.
Because of its water-soluble nature, midazolam has a rapid onset of action and can be used to manage status epilepticus when intravenous administration of other medications is not feasible. Midazolam can be used for anxiolysis and hypnosis during the maintenance phase of general anesthesia.