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  2. Midazolam - Wikipedia

    en.wikipedia.org/wiki/Midazolam

    Midazolam is known to cause respiratory depression. In healthy humans, 0.15 mg/kg of midazolam may cause respiratory depression, which is postulated to be a central nervous system (CNS) effect. [48] When midazolam is administered in combination with fentanyl, the incidence of hypoxemia or apnea becomes more likely. [49]

  3. List of benzodiazepines - Wikipedia

    en.wikipedia.org/wiki/List_of_benzodiazepines

    Peak Onset of Action (hours) Elimination Half-life of Active Metabolite ... Midazolam: Dormicum, Flormidal, Versed, Hypnovel, Dormonid: 1985 7.5, 15 10 (oral)

  4. Benzodiazepine - Wikipedia

    en.wikipedia.org/wiki/Benzodiazepine

    Midazolam 1 & 5 mg/mL injections (Canada). Benzodiazepines possess psycholeptic, sedative, hypnotic, anxiolytic, anticonvulsant, muscle relaxant, and amnesic actions, [4] [5] which are useful in a variety of indications such as alcohol dependence, seizures, anxiety disorders, panic, agitation, and insomnia.

  5. Diazepam - Wikipedia

    en.wikipedia.org/wiki/Diazepam

    The onset of action is one to five minutes for IV administration and 15–30 minutes for IM administration. The duration of diazepam's peak pharmacological effects is 15 minutes to one hour for both routes of administration. [68] The half-life of diazepam, in general, is 30–56 hours. [1]

  6. Rapid sequence induction - Wikipedia

    en.wikipedia.org/wiki/Rapid_sequence_induction

    It has slow onset of action when used alone, but the onset can be improved when using together with an opioid. [9] However, for those with hypotension, midazolam can further reduce the blood pressure and has cardiac depressive effects. [14] Therefore, dose reduction is required for the elderly, and for those with heart and liver failure. [8]

  7. NYT ‘Connections’ Hints and Answers Today, Tuesday, February 4

    www.aol.com/nyt-connections-hints-answers-today...

    Spoilers ahead! We've warned you. We mean it. Read no further until you really want some clues or you've completely given up and want the answers ASAP. Get ready for all of today's NYT ...

  8. Benzodiazepine withdrawal syndrome - Wikipedia

    en.wikipedia.org/wiki/Benzodiazepine_withdrawal...

    The authors also warned of the similarities in pharmacology and mechanism of action of the newer nonbenzodiazepine Z drugs. [136] The elimination half-life of diazepam and chlordiazepoxide, as well as other long half-life benzodiazepines, is twice as long in the elderly compared to younger individuals. Many doctors do not adjust benzodiazepine ...

  9. Ketamine - Wikipedia

    en.wikipedia.org/wiki/Ketamine

    The discovery of antidepressive action of ketamine in 2000 [144] has been described as the single most important advance in the treatment of depression in more than 50 years. [ 61 ] [ 11 ] It has sparked interest in NMDA receptor antagonists for depression, [ 145 ] and has shifted the direction of antidepressant research and development.