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Protein tyrosine phosphatase non-receptor type 5 is an enzyme that in humans is encoded by the PTPN5 gene. [5] [6]Protein tyrosine phosphatase (), non-receptor type 5, also known as STEP (STriatal-Enriched protein tyrosine Phosphatase), was the first brain-specific PTP discovered. [5]
Ser/Thr and Tyr dual-specificity phosphatases are a group of enzymes with both Ser/Thr (EC 3.1.3.16) and tyrosine-specific protein phosphatase (EC 3.1.3.48) activity able to remove the serine/threonine or the tyrosine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under ...
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
PTPmu tyrosine phosphatase activity is activated by shear stress. [73] Caveolin 1 is a scaffolding protein enriched in endothelial cell junctions that is also linked to shear stress regulated responses. [73] Caveolin 1 is dephosphorylated on tyrosine 14 in response to shear stress and PTPmu is hypothesized to catalyze this reaction. [73]
Receptor-type tyrosine-protein phosphatase kappa is an enzyme that in humans is encoded by the PTPRK gene. [ 5 ] [ 6 ] [ 7 ] PTPRK is also known as PTPkappa and PTPκ. Function
The striatum (pl.: striata) or corpus striatum [5] is a cluster of interconnected nuclei that make up the largest structure of the subcortical basal ganglia. [6] The striatum is a critical component of the motor and reward systems; receives glutamatergic and dopaminergic inputs from different sources; and serves as the primary input to the rest of the basal ganglia.
Tyrosine-protein phosphatase non-receptor type 1 also known as protein-tyrosine phosphatase 1B (PTP1B) is an enzyme that is the founding member of the protein tyrosine phosphatase (PTP) family. In humans it is encoded by the PTPN1 gene . [ 5 ]
5794 545902 Ensembl ENSG00000080031 ENSMUSG00000035429 UniProt Q9HD43 E9Q0N2 RefSeq (mRNA) NM_001161440 NM_002842 NM_207270 RefSeq (protein) NP_001154912 NP_002833 NP_997153 Location (UCSC) Chr 19: 55.18 – 55.21 Mb Chr 7: 4.55 – 4.61 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH ...