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Goals are to increase public awareness about dengue, mobilize resources for its prevention and control and, to demonstrate the Southeast Asian region's commitment in tackling the disease. [93] Efforts are ongoing as of 2019 to make it a global event. [94] The Philippines has an awareness month in June since 1998. [95] [96]
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Dengue virus (DENV) is the cause of dengue fever.It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. [1] [2] Four serotypes of the virus have been found, and a reported fifth has yet to be confirmed, [3] [4] [5] all of which can cause the full spectrum of disease. [1]
Epidemic dengue has become more common since the 1980s. By the late 1990s, dengue was the most important mosquito-borne disease affecting humans after malaria, with around 40 million cases of dengue fever and several hundred thousand cases of dengue hemorrhagic fever each year. Significant outbreaks of dengue fever tend to occur every five or ...
Dengue vaccine is a vaccine used to prevent dengue fever in humans. [9] Development of dengue vaccines began in the 1920s but was hindered by the need to create immunity against all four dengue serotypes. [10] As of 2023, there are two commercially available vaccines, sold under the brand names Dengvaxia and Qdenga. [11] [12]
The process of climate change has produced abundant rains and high temperatures, (a phenomenon called tropicalization) favouring the reproduction of the mosquito that transmits the dengue virus, advancing the epidemic this year by several weeks compared to previous seasons, which historically, Infection peaks tended to occur between March and April, suggesting a continued increase in cases. [11]
In a small proportion of cases the disease develops into the life-threatening dengue hemorrhagic fever, resulting in hemorrhage, thrombocytopenia and blood plasma leakage, or into dengue shock syndrome, where shock occurs. Dengue is transmitted by several species of mosquito within the genus Aedes, principally A. aegypti.
Dengue is a Flaviviridae virus, with five genetic types. [ 8 ] [ 9 ] Here is the virus drawn as a 3-dimensional model of the envelope protein. [ 10 ] Dengue is in the same family as other well known viruses carried by mosquitoes that cause tropical diseases, such as yellow fever , West Nile , and Zika virus .
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