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Intrinsic ageing and extrinsic ageing are terms used to describe cutaneous ageing of the skin and other parts of the integumentary system, which while having epidermal concomitants, seems to primarily involve the dermis. [1] Intrinsic ageing is influenced by internal physiological factors alone, and extrinsic ageing by many external factors.
Primary prevention aims to reduce the risk factors before a disease or condition occurs. Sun protection is the most effective form of primary prevention of photoaging. The major methods of sun protection are sunscreen products, sun protective clothing , and reducing exposure to the sun, especially during peak sun hours (10 AM-4PM in the spring ...
Conditions of or affecting the human integumentary system associated with increased risk of nonmelanoma skin cancer Condition Squamous-cell carcinoma Basal-cell carcinoma; Xeroderma pigmentosum + + Oculocutaneous albinism + + Epidermodysplasia verruciformis + Recessive dystrophic epidermolysis bullosa + Ferguson–Smith syndrome + Muir–Torre ...
DNA cross-linking can in turn lead to various effects of aging, especially cancer. [21] Other cross-linking can occur between fat and protein molecules, which leads to wrinkles. [22] Free radicals can oxidize LDL, and this is a key event in the formation of plaque in arteries, leading to heart disease and stroke. [23]
Aging is characterized by the declining ability to respond to stress, increased homeostatic imbalance, and increased risk of aging-associated diseases including cancer and heart disease. Aging has been defined as "a progressive deterioration of physiological function, an intrinsic age-related process of loss of viability and increase in ...
The most significant risk factor for developing cancer is age. [211] Although it is possible for cancer to strike at any age, most patients with invasive cancer are over 65. [211] According to cancer researcher Robert A. Weinberg, "If we lived long enough, sooner or later we all would get cancer."
Prolonged exposure is associated with the development of skin cancers, photoaging or premature skin aging, immune suppression, and eye diseases like cataracts. [14] [15] Given these dual effects, public health organizations emphasize the importance of striking a balance between the benefits and risks of UV exposure.
Ageing is associated with increased risk of cancer, Alzheimer's disease, diabetes, cardiovascular disease, increased mental health risks, and many more. [ 4 ] [ 5 ] Of the roughly 150,000 people who die each day across the globe, about two-thirds die from age-related causes. [ 6 ]