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Extrinsic ageing of skin is a distinctive declination process caused by external factors, which include ultra-violet radiation, cigarette smoking, air pollution, among others. Of all extrinsic causes, radiation from sunlight has the most widespread documentation of its negative effects on the skin.
Prolonged exposure is associated with the development of skin cancers, photoaging or premature skin aging, immune suppression, and eye diseases like cataracts. [14] [15] Given these dual effects, public health organizations emphasize the importance of striking a balance between the benefits and risks of UV exposure.
UV radiation decreases the expression of both retinoic acid receptors and retinoid X receptors in human skin, thereby resulting in a complete loss of the induction of RA-responsive genes. It also leads to an increase in activity of the AP-1 pathway, increasing MMP activity and thus resulting in a functional deficiency of vitamin A in the skin.
Exposure to non-ionizing ultraviolet light is a risk factor for developing skin cancer (especially non-melanoma skin cancers), sunburn, premature aging of skin, and other effects. Despite the possible hazards it is beneficial to humans in the right dosage, since Vitamin D is produced due to the biochemical effects of ultraviolet light.
The most common health hazard of radiation is sunburn, which causes between approximately 100,000 and 1 million new skin cancers annually in the United States. [ 3 ] [ 4 ] In 2011, the World Health Organization (WHO) and the International Agency for Research on Cancer (IARC) have classified radiofrequency electromagnetic fields as possibly ...
Fitzpatrick scale: Influence of pigmentation on skin cancer risk. Exposure to ultraviolet radiation (UVR), whether from outdoor tanning under the sun or indoor tanning using tanning devices is known to be a major cause of the three main types of skin cancer: non-melanoma skin cancer (basal cell carcinoma and squamous cell carcinoma) and melanoma.
The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. [1] A free radical is any atom or molecule that has a single unpaired electron in an outer shell. [2] While a few free radicals such as melanin are not chemically reactive, most biologically relevant free radicals are highly ...
Ionizing radiation is generally harmful and potentially lethal to living things but can have health benefits in radiation therapy for the treatment of cancer and thyrotoxicosis. Its most common impact is the induction of cancer with a latent period of years or decades after exposure.