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It is thought that the Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. [4] The Swedish mutation mice are used to study the effects of amyloid plaques and to develop potential treatments for Alzheimer's disease. [5]
It is an uncommon form of Alzheimer's, accounting for only 5–10% of all Alzheimer's cases. About 60% have a positive family history of Alzheimer's and 13% of them are inherited in an autosomal dominant manner. Most cases of early-onset Alzheimer's share the same traits as the "late-onset" form and are not caused by known genetic mutations.
The cause for most Alzheimer's cases is still mostly unknown, [14] except for 1–2% of cases where deterministic genetic differences have been identified. [17] Several competing hypotheses attempt to explain the underlying cause; the most predominant hypothesis is the amyloid beta (Aβ) hypothesis. [14]
RESEARCH POINTS TO A CAUSE FOR A SUBSET OF ALZHEIMER'S. To better understand the gene’s role, Fortea’s team used data from 3,297 brains donated for research and from over 10,000 people in U.S ...
Alzheimer’s usually is a disease of people over age 65 and while simply getting older is the main risk, the APOE gene has long been known to play some role. It comes in three main varieties.
A main theory behind the cause of Alzheimer’s disease is the build-up of the protein amyloid-beta in the brain. ... “Even in those with genetic forms of Alzheimer’s disease, ...
Several genetic, cell biology, biochemical and animal studies using experimental models support the concept that Aβ plays a central role in the development of Alzheimer's disease pathology. [33] [34] Brain Aβ is elevated in people with sporadic Alzheimer's disease.
The biochemistry of Alzheimer's disease, the most common cause of dementia, is not yet very well understood. Alzheimer's disease (AD) has been identified as a proteopathy: a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain. [1]
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