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As Parkinson's is a heterogeneous condition with multiple etiologies, prognostication can be difficult and prognoses can be highly variable. [220] [222] On average, life expectancy is reduced in those with Parkinson's, with younger age of onset resulting in greater life expectancy decreases. [223]
Parkinsonism is a clinical syndrome characterized by tremor, bradykinesia (slowed movements), rigidity, and postural instability. [ 1 ] [ 2 ] Both hypokinetic (bradykinesia and akinesia) as well as hyperkinetic (cogwheel rigidity and tremors at rest) features are displayed by Parkinsonism. [ 3 ]
Kufor–Rakeb syndrome is associated with mutations in the ATP13A2 gene. [8] The inheritance pattern for KRS is autosomal recessive. [9] If a male and female carrier, who each have one mutation in ATP13A2 have a child, there is a 25% chance the child has KRS, a 50% chance the child is a carrier for KRS, and a 25% chance the child does not have KRS.
[2] [3] Life2vec is a transformer-based model, similar to those used in natural language processing (e.g., ChatGPT or Llama), trained to analyze life trajectories. The project leverages rich registry data from Denmark, covering six million individuals, with event data related to health, demographics, and labor, recorded at a day-to-day ...
Multiple system atrophy is estimated to affect approximately 5 per 100,000 people. At autopsy, many patients diagnosed during life with Parkinson's disease are found actually to have MSA, suggesting that the actual incidence of MSA is higher than that estimate. [4]
The organization notes that the average life expectancy for Parkinson’s disease in 1967 was "a little under 10 years" from the time of diagnosis. Now, that statistic has grown to 14.5 years or ...
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Parkinson-plus syndromes are usually more rapidly progressive and less likely to respond to antiparkinsonian medication than PD. [10] [11] However, the additional features of the diseases may respond to medications not used in PD. [citation needed] Current therapy for Parkinson-plus syndromes is centered around a multidisciplinary treatment of ...
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