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Reelin's name comes from the abnormal reeling gait of reeler mice, [17] which were later found to have a deficiency of this brain protein and were homozygous for mutation of the RELN gene. The primary phenotype associated with loss of reelin function is a failure of neuronal positioning throughout the developing central nervous system (CNS).
The Disabled-1 (Dab1) gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells. DAB1 functions downstream of Reln in a signaling pathway that controls cell positioning in the developing brain and during adult neurogenesis.
The examples include: Double knockout of VLDLR and ApoER2 receptors; [5] Double knockout of Src and Fyn kinases. [6] Cre-loxP recombination mice model that lacks Crk and CrkL in most neurons. [7] Was used to show that Crk/CrkL lie downstream of DAB1] in the reelin signaling pathway. Scrambler mouse; Brain slices of wildtype and reeler mice
Both the "compatibility" function STDEVP and the "consistency" function STDEV.P in Excel 2010 return the 0.5 population standard deviation for the given set of values. However, numerical inaccuracy still can be shown using this example by extending the existing figure to include 10 15 , whereupon the erroneous standard deviation found by Excel ...
The full-length human VLDLR genome is located on locus 9p24 on chromosome 9. It consists of a 40 kb segment that includes 19 exon -coding sequences, which is one more exon than encoded by LDLR . This extra exon in the VLDLR gene accounts for the extra cysteine-binding repeat not found in LDLR. [ 7 ]
A reference dimension is a dimension on an engineering drawing provided for information only. [1] Reference dimensions are provided for a variety of reasons and are often an accumulation of other dimensions that are defined elsewhere [2] (e.g. on the drawing or other related documentation). These dimensions may also be used for convenience to ...
The size and proportions of a book depend on the size of the original full sheet. If a sheet 480 by 640 mm (19 by 25 in) is used to print a quarto, the resulting untrimmed pages, will be approximately half as large in each dimension: width 240 mm ( 9 + 1 ⁄ 2 in) and height 320 mm ( 12 + 1 ⁄ 2 in).
A check sheet is a form (document) used to collect data in real time at the location where the data is generated. The data it captures can be quantitative or qualitative. When the information is quantitative, the check sheet is sometimes called a tally sheet. [1] The check sheet is one of the so-called Seven Basic Tools of Quality Control. [2]