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Rh disease (also known as rhesus isoimmunization, Rh (D) disease, or rhesus incompatibility, and blue baby disease) is a type of hemolytic disease of the fetus and newborn (HDFN). HDFN due to anti-D antibodies is the proper and currently used name for this disease as the Rh blood group system actually has more than 50 antigens and not only the ...
James Christopher Harrison OAM (27 December 1936 – 17 February 2025) was an Australian blood plasma donor whose plasma contained antibodies that made it valuable for treatment against Rh disease. Known as the "Man with the Golden Arm", he donated 1,173 times from age 18 to 81, making his final donation on 11 May 2018.
Rhesus c HDFN can range from a mild to severe disease and is the third most common form of severe HDN. [19] Rhesus e and rhesus C hemolytic disease of the newborn are rare. Anti-C and anti-c can both show a negative DAT but still have a severely affected infant. [20] [21] An indirect Coombs must also be run.
The 88-year-old, nicknamed “the man with the golden arm,” donated blood plasma more than 1,100 times to protect unborn babies from Rhesus D Haemolytic Disease, according to the organization.
Harrison’s rare antibodies were crucial in developing Anti-D, the treatment that has protected millions of newborns from Rhesus disease (or Haemolytic Disease of the Foetus and Newborn) – a ...
The risk of hemolytic disease (including due to RhD) significantly increases if the mother has had a past transfusion of Rh-positive blood. [ 10 ] Exposure to fetal blood cells that can cause RhD alloimmunization can happen during normal pregnancy and delivery, miscarriage, amniocentesis, cordocentesis, chorionic villus sampling, external ...
The name rhesus factor (Rh) goes back to the use of erythrocytes extracted from the blood of rhesus monkeys for obtaining the first blood serum. The Rh blood group system is a human blood group system. It contains proteins on the surface of red blood cells. After the ABO blood group system, it is most likely to be involved in transfusion reactions.
John Grant Gorman AC, (born c. 1931) [1] is an Australian physician and medical researcher. In 1980, Gorman shared the Lasker-DeBakey Clinical Medical Research Award for pioneering work on the rhesus blood group system, the role of rhesus D antibodies in the causation of Rh disease and the apparently paradoxical prevention of Rh disease using the Rh antibodies themselves, in the form of Rho(D ...