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Apixaban is recommended by the National Institute for Health and Clinical Excellence for the prevention of stroke and systemic embolism in people with non-valvular atrial fibrillation and at least one of the following risk factors: prior stroke or transient ischemic attack, age 75 years or older, diabetes, or symptomatic heart failure.
Antistasin, the first discovered naturally occurring direct Xa inhibitor Rivaroxaban, the first synthetic direct Xa inhibitor marketed as a drug Prior to the introduction of direct factor Xa inhibitors, vitamin K antagonists such as warfarin were the only oral anticoagulants for over 60 years, and together with heparin have been the main blood ...
The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...
Image of a European female (left) and an East Asian male (right) human body seen from front (upper) and back (lower). Adult human bodies photographed whose naturally-occurring pubic, body, facial, but not head hair have been deliberately removed to show anatomy. Retouched with anterior and posterior views.
Some researches shows gross measures of body strength suggest that females are approximately 50-60% as strong as males in the upper body, and 60-70% as strong in the lower body. [33] One study of muscle strength in the elbows and knees —in 45 and older males and females—found the strength of females to range from 42 to 63% of male strength ...
It does so primarily by acting on the mineralocorticoid receptors in the distal tubules and collecting ducts of the nephron. [6] It influences the reabsorption of sodium and excretion of potassium (from and into the tubular fluids, respectively) of the kidney , thereby indirectly influencing water retention or loss, blood pressure , and blood ...
Body temperature. Movement. Snoring. Oxygen consumption. Dangers During Hibernation. Bears can face a number of dangers while in hibernation, and surprisingly, humans are one of them. If a human ...
An anticoagulant, commonly known as a blood thinner, is a chemical substance that prevents or reduces the coagulation of blood, prolonging the clotting time. [1] Some occur naturally in blood-eating animals, such as leeches and mosquitoes, which help keep the bite area unclotted long enough for the animal to obtain blood.