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HIV disease–related drug reaction is an adverse drug reaction caused by drugs used for the treatment of HIV/AIDS. Image of common antiretroviral drugs to treat HIV infection [ 1 ] Drug reactions are a major cause of mortality and morbidity around the world.
Schematic description of the mechanism of the four classes of available antiretroviral drugs against HIV. There are six classes of drugs, which are usually used in combination, to treat HIV infection. Antiretroviral (ARV) drugs are broadly classified by the phase of the retrovirus life-cycle that the drug inhibits. Typical combinations include ...
It works by inhibiting the enzyme reverse transcriptase that HIV uses to make DNA and therefore decreases replication of the virus. [6] Zidovudine was first described in 1964. [7] It was resynthesized from a public-domain formula by Burroughs Wellcome. [8] It was approved in the United States in 1987 and was the first treatment for HIV.
Rilpivirine, sold under the brand name Edurant among others, is a medication, developed by Tibotec, used for the treatment of HIV/AIDS. [6] [7] It is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs such as efavirenz.
The human immunodeficiency virus (HIV) [8] [9] [10] is a retrovirus [11] that attacks the immune system.It is a preventable disease. [5] It can be managed with treatment and become a manageable chronic health condition. [5]
Its FDA approval helped bring down the price of zidovudine (ZDV), the initial anti-HIV drug. [citation needed] Didanosine has weak acid stability and is easily damaged by stomach acid. Therefore, the original formula approved by the FDA used chewable tablets that included an antacid buffering compound to neutralize stomach acid. The chewable ...
Saquinavir, sold under the brand name Invirase among others, is an antiretroviral medication used together with other medications to treat or prevent HIV/AIDS. [4] Typically it is used with ritonavir or lopinavir/ritonavir to increase its effect. [4] It is taken by mouth. [4] Common side effects include nausea, vomiting, diarrhea, and feeling ...
The liver problems and skin rash may be severe and should be checked for during the first few months of treatment. [ 5 ] [ 6 ] It appears to be safe for use during pregnancy . [ 5 ] It is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and works by blocking the function of reverse transcriptase .
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