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Phenytoin acts by inhibiting this enzyme, thereby causing folate deficiency, and thus megaloblastic anemia. [25] Other side effects may include: agranulocytosis, [26] aplastic anemia, [27] decreased white blood cell count, [28] and a low platelet count. [29]
Purple glove syndrome is caused by the intravenous anticonvulsant phenytoin. [3] This medication has many already established neurological side effects. However, glove syndrome is a rare, with prevalence ranging from 1.7% to 5.9%, but has very serious adverse effect that may lead to limb amputations.
Before oral antifungal therapies are used to treat nail disease, a confirmation of the fungal infection should be made. [36] Approximately half of suspected cases of fungal infection in nails have a non-fungal cause. [36] The side effects of oral treatment are significant and people without an infection should not take these drugs. [36]
Fetal hydantoin syndrome, also called fetal dilantin syndrome, is a group of defects caused to the developing fetus by exposure to teratogenic effects of phenytoin. Dilantin is the brand name of the drug phenytoin sodium in the United States, commonly used in the treatment of epilepsy .
Many side effects and adverse drug reactions have been reported with oral terbinafine hydrochloride, [12] [13] possibly due to its extensive biodistribution and the often extended durations involved in antifungal treatment (longer than two months). A comprehensive list of adverse events associated with terbinafine use includes:
The side effects of ketoconazole are sometimes harnessed in the treatment of non-fungal conditions. While ketoconazole blocks the synthesis of the sterol ergosterol in fungi, in humans, at high dosages (>800 mg/day), it potently inhibits the activity of several enzymes necessary for the conversion of cholesterol to steroid hormones such as ...
As interest in taking glucagon-like peptide-1 receptor agonist (GLP-1 agonist) medications, such as Zepbound and Wegovy, for weight loss, research continues to examine potential new side effects ...
Sulfonylureas — effects enhanced; Phenytoin, half-life of phenytoin is increased; Antifolates like pyrimethamine, proguanil and methotrexate increase the risk of associated side effects like bone marrow toxicity, folic acid supplementation should be considered. A significant risk of megaloblastic anaemia exists with doses of pyrimethamine in ...
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