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Nortriptyline is an active metabolite of amitriptyline by demethylation in the liver. Chemically, it is a secondary amine dibenzocycloheptene and pharmacologically it is classed as a first-generation antidepressant. [36] Nortriptyline may also have a sleep-improving effect due to antagonism of the H 1 and 5-HT 2A receptors. [37]
Venous leak, also called venogenic erectile dysfunction and penile venous insufficiency, is one category of vascular-induced (vasculogenic) impotence – a cause of erectile dysfunction in males. [2] It affects all ages, being particularly awkward in young men. [ 3 ]
Viagra is an effective ED treatment that can improve performance, make arousals firmer, and improve your intimate life. Since those benefits are attractive whether you have ED or not, some men ...
It is the most common sexual problem in males and can cause psychological distress due to its impact on self-image and sexual relationships. The majority of ED cases are attributed to physical risk factors and predictive factors. These factors can be categorized as vascular, neurological, local penile, hormonal, and drug-induced.
Erectile dysfunction can cause a “self-perpetuating cycle of anxiety and performance pressure,” says one expert. (Photo illustration: Victoria Ellis for Yahoo News; photo: Getty Images) (Photo ...
The best treatment for winter erectile dysfunction will depend on the root cause. ED (and especially winter erectile dysfunction) can often be traced back to conditions or factors affecting the ...
Nortriptyline reaches 10% higher level in the blood plasma than the parent drug amitriptyline and 40% greater area under the curve, and its action is an important part of the overall action of amitriptyline. [5] [9] Another active metabolite is (E)-10-hydroxynortriptyline, which is a norepinephrine uptake inhibitor four times weaker than ...
The causes of pelvic floor dysfunction aren’t well understood. Experts know that weakened muscles and connective tissue in the pelvis can contribute to it, as can injuries to the pelvis.
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