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Histopathologically, FMTs consist of neoplastic connective tissue cells which have differented into cells that have microscopic appearances resembling fibroblasts and/or myofibroblasts. The fibroblastic cells are characterized as spindle-shaped cells with inconspicuous nucleoli that express vimentin , an intracellular protein typically found in ...
Breast MFB has also been reported to develop at a surgical scar left after treatment for breast cancer and in patients with a history of prostate, kidney, and pancreatic cancer. [14] This tumor typically presents as a single, firm, mobile, painless mass; presentation as multiple masses is extremely rare. [14]
A cancer-associated fibroblast (CAF) (also known as tumour-associated fibroblast; carcinogenic-associated fibroblast; activated fibroblast) is a cell type within the tumor microenvironment that promotes tumorigenic features by initiating the remodelling of the extracellular matrix or by secreting cytokines.
Clinical presentation of a lump in the breast is histologically viewed as a collagenous tumor or desmoplastic response created by myofibroblasts of the tumor stroma. [18] Proposed mechanisms of activation of myofibroblasts are by immune cytokine signaling, microvascular injury, or paracrine signaling by tumor cells.
Myofibroblasts may interfere with the propagation of electrical signals [5] controlling heart rhythm, [6] leading to arrhythmia in both patients who have suffered a heart attack and in foetuses. Ursodiol is a promising drug for this condition. [7]
Sclerosing epithelioid fibrosarcoma (SEF) is a very rare malignant tumor of soft tissues that on microscopic examination consists of small round or ovoid neoplastic epithelioid fibroblast-like cells, i.e. cells that have features resembling both epithelioid cells and fibroblasts. [1]
Former First Lady of the United States, Nancy Reagan (1921–2016) was a long-term breast cancer survivor.. This list of notable breast cancer patients includes people who made significant contributions to their respective fields and who were diagnosed with breast cancer at some point in their lives, as confirmed by public information.
For example, it is both relatively sensitive and specific for detection of breast cancer metastasis to sentinel lymph nodes. [3] It may cross-react with GFAP, leading to aberrant staining of glial tumors such as ependymoma, glioblastoma and schwannoma. [1] It may also stain myofibroblasts and smooth muscle cells. [1]
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